Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection.

Thesis

In addition to a central circadian clock in the suprachiasmatic nucleus (SCN), zebrafish (Danio rerio) have local clock systems in their peripheral tissues. These peripheral tissues express a complement of clock genes that can be synchronized with the 24 h light/dark cycle and thus may be entrained by light. To date, teleost multiple tissue (tmt) opsin identified from Fugu rubripes and Danio rerio is the only opsin that has been proposed as a candidate to mediate this cellular photoentrain...

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Authors: Fu, J

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Photopigment; G protein-coupled receptor; Photosensory; Multiple Tissue expression; Opsin; Transduction; Biological rhythms
• Subjects: Medical sciences; Cell Biology; Biology (medical sciences); DNA damage signalling; Life Sciences; Physical Sciences; Molecular biophysics (biochemistry); Biology; Photochemistry and reaction dynamics; Physiology; Genetics (medical sciences); Ophthamology; Biochemistry; Molecular genetics; Genetics (life sciences); Protein chemistry; Bioinformatics (biochemistry); Protein folding; Membrane proteins; Biophysics; Spectroscopy and molecular structure; Bioinformatics (life sciences)