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Optogenetic control of heart rhythm by selective stimulation of cardiomyocytes derived from Pnmt+ cells in murine heart

Abstract:

In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class of Pnmt-expressing neuroendocrine cells and their descendants (i.e. Pnmt+ cell derived cells) within the heart. Here, we show that Pnmt+ cells predominantly localized to the lef...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep40687

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Department:
Oxford, MSD, Pharmacology
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Department:
Oxford, MSD, Pharmacology
Crawford, W More by this author
Bolton, EL More by this author
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Grant:
PG/14/80/31106; PG/16/67/32340
BHF Centre of Research Excellence - Oxford Cardiovascular Science More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
Article: 40687
Publication date:
2017
Acceptance date:
2016-12-08
DOI:
ISSN:
2045-2322
Pubs id:
pubs:666148
URN:
uri:39b36814-ec0d-4091-9fd6-e4241c9c1a9a
UUID:
uuid:39b36814-ec0d-4091-9fd6-e4241c9c1a9a
Local pid:
pubs:666148

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