Journal article
Optogenetic control of heart rhythm by selective stimulation of cardiomyocytes derived from Pnmt+ cells in murine heart
- Abstract:
-
In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline. The new murine model enabled the identification of a distinctive class of Pnmt-expressing neuroendocrine cells and their descendants (i.e. Pnmt+ cell derived cells) within the heart. Here, we show that Pnmt+ cells predominantly localized to the lef...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
BHF Centre of Research Excellence - Oxford Cardiovascular Science
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Article number:
- 40687
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-12-08
- DOI:
- ISSN:
-
2045-2322
Item Description
- Pubs id:
-
pubs:666148
- UUID:
-
uuid:39b36814-ec0d-4091-9fd6-e4241c9c1a9a
- Local pid:
- pubs:666148
- Source identifiers:
-
666148
- Deposit date:
- 2016-12-23
Terms of use
- Copyright holder:
- Wang et al
- Copyright date:
- 2017
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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