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Thesis

Signal processing methods for characterisation of ventricular repolarisation using the surface electrocardiogram

Abstract:

This thesis investigates the mechanisms underlying drug-induced arrhythmia and pro- poses a new approach for the automated analysis of the electrocardiogram (ECG). The current method of assessing the cardiac safety of new drugs in clinical trials is by the measurement and analysis of the QT interval. However, the sensitivity and specificity of the QT interval has been questioned and alternative biomarkers based on T-wave mor- phology have been proposed in the literature. The mechanisms und...

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Institution:
University of Oxford
Research group:
Biomedical Signal Processing & e-health
Oxford college:
Keble College
Department:
Mathematical,Physical & Life Sciences Division - Engineering Science

Contributors

Role:
Supervisor
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Funding agency for:
Thomas Brennan
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:39ae285a-b8dd-4aae-b60e-36f95fb84f37
Local pid:
ora:5406

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