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Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice.

Abstract:

Insulin-like growth factor-II (IGF-II) is an embryonic growth promoter and cell survival factor. IGF-II supply is normally limited by gene expression because transcription occurs predominantly from the paternal allele in mouse and man (maternal imprinting). Excess IGF-II has detrimental systemic and local effects in vivo, promoting somatic overgrowth and an increased frequency of tumors. IGF2 mRNA is overexpressed in colorectal and many other human cancers. In this paper, we show that altered...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology
Role:
Author
Journal:
Cancer research
Volume:
60
Issue:
4
Pages:
1070-1076
Publication date:
2000-02-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:39a7bddc-370c-4dc3-b508-e1a9f8b2ca4f
Source identifiers:
458583
Local pid:
pubs:458583

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