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Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

Abstract:

Malaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality con...

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Publication status:
Published

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Publisher copy:
10.1038/nature11174

Authors


Campino, S More by this author
Almagro-Garcia, J More by this author
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Journal:
Nature
Volume:
487
Issue:
7407
Pages:
375-379
Publication date:
2012-07-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:398b526d-1ff9-4b93-95a4-caea3a746679
Source identifiers:
323975
Local pid:
pubs:323975

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