Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

Manske, M; Miotto, O; Campino, S; Auburn, S; Almagro-Garcia, J; Maslen, G; O'Brien, J; Djimde, A; Doumbo, O; Zongo, I; Ouedraogo, JB; Michon, P; Mueller, I; Siba, P; Nzila, A; Borrmann, S; Kiara, SM; Marsh, K; Jiang, H; Su, XZ; Amaratunga, C; Fairhurst, R; Socheat, D; Nosten, F; Imwong, M; White, NJ; Sanders, M; Anastasi, E; Alcock, D; Drury, E; Oyola, S; Quail, MA; Turner, DJ; Ruano-Rubio, V; Jyothi, D; Amenga-Etego, L; Hubbart, C; Jeffreys, A; Rowlands, K; Sutherland, C; Roper, C; Mangano, V; Modiano, D; Tan, JC; Ferdig, MT; Amambua-Ngwa, A; Conway, DJ; Takala-Harrison, S; Plowe, CV; Rayner, JC; Rockett, KA; Clark, TG; Newbold, CI; Berriman, M; MacInnis, B; Kwiatkowski, DP

Abstract:

Malaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality con...

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APA Style

Manske, M., Miotto, O., Campino, S., Auburn, S., Almagro-Garcia, J., Maslen, G., O'Brien, J., Djimde, A., Doumbo, O., Zongo, I., Ouedraogo, J. B., Michon, P., Mueller, I., Siba, P., Nzila, A., Borrmann, S., Kiara, S. M., Marsh, K., Jiang, H., … Kwiatkowski, D. P. (2012). Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature, 487(7407), 375–379.

MLA Style

Manske, M., et al. “Analysis of Plasmodium Falciparum Diversity in Natural Infections by Deep Sequencing.” Nature, vol. 487, no. 7407, Nature, 2012, pp. 375–79.

Chicago Style

Manske, M, O Miotto, S Campino, S Auburn, J Almagro-Garcia, G Maslen, J O'Brien, et al. 2012. “Analysis of Plasmodium Falciparum Diversity in Natural Infections by Deep Sequencing.” Nature 487 (7407): 375–79.
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