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Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy.

Abstract:

Axonal damage is a major factor contributing to permanent disability in patients with multiple sclerosis (MS); it has been extensively investigated in the brain using magnetic resonance spectroscopy (MRS). In this study, MRS was used to investigate the degree of neuronal damage in the cervical spinal cord in MS. Spectra were acquired from spinal cord and brain in 11 patients with MS (expanded disability status score [EDSS], range 2.5-7.0) and 11 controls. Brain lesion volume and spinal cord c...

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Publication status:
Published

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Publisher copy:
10.1002/mrm.21382

Authors


Blamire, AM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Matthews, PM More by this author
Journal:
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume:
58
Issue:
5
Pages:
880-885
Publication date:
2007-11-05
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:39888fca-5755-4052-a027-ed9b81612f01
Source identifiers:
241566
Local pid:
pubs:241566

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