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Journal article

Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.

Abstract:

Matrix metalloproteinase (MMP)-1 and MMP-3 levels were measured in serum samples from rheumatoid arthritis (RA) patients undergoing a double-blinded placebo-controlled trial with the chimaeric anti-tumour necrosis factor (TNF)-alpha antibody cA2. Both MMP-1 (P < 0.015), but to a larger extent MMP-3 (P < 0.001) levels were elevated in all RA patients prior to the commencement of the trial compared with normal control sera. Following cA2 therapy, MMP-1 and MMP-3 levels were assessed in th...

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Publication status:
Published

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Authors


Brennan, FM More by this author
Browne, KA More by this author
Jaspar, JM More by this author
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Journal:
British journal of rheumatology
Volume:
36
Issue:
6
Pages:
643-650
Publication date:
1997-06-05
ISSN:
0263-7103
URN:
uuid:398817cf-2ecb-4b72-9fa0-ab5721edb6f4
Source identifiers:
481608
Local pid:
pubs:481608

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