Cellular cap-binding proteins associate with influenza virus mRNAs.

Journal article

The influenza virus RNA polymerase synthesizes three types of RNA: genomic vRNA, anti-genomic cRNA and mRNA. Both vRNA and cRNA are bound by the viral RNA polymerase and nucleoprotein to form ribonucleoprotein complexes. Viral mRNAs are also proposed to be bound by the RNA polymerase to prevent their endonucleolytic cleavage, regulate the splicing of M1 mRNA, and facilitate translation. Here, we used standard immunoprecipitation, biochemical purification and RNA immunoprecipitation assays to ...

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Authors: Bier, K; York, A; Fodor, E

• Publication status: Published
• Journal: Journal of general virology
• Volume: 92
• Issue: Pt 7
• Pages: 1627-1634
• Publication date: 2011-07-01
• DOI: 10.1099/vir.0.029231-0
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Viral Proteins; RNA, Viral; Protein Binding; Poly(A)-Binding Protein I; Humans; Influenza, Human; Influenza A virus; Nuclear Cap-Binding Protein Complex; RNA, Messenger; Cell Line; DNA-Directed RNA Polymerases