Review: Does size matter? Placental debris and the pathophysiology of pre-eclampsia.

Journal article

A variety of 'debris' is shed from the syncytial surface of the human placenta ranging from large deported multinuclear fragments to sub-cellular components. It is increasingly clear that at least some of this material has signalling functions. Many categories of circulating debris are increased in pre-eclampsia, and exhibit proteins that are pro-inflammatory and could contribute to the systemic inflammatory response in normal pregnancy, which is exaggerated in pre-eclampsia. It is now eviden...

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Authors: Redman, C; Tannetta, D; Dragovic, R; Gardiner, C; Southcombe, J

• Publication status: Published
• Journal: Placenta
• Volume: 33 Suppl
• Pages: S48-S54
• Publication date: 2012-02-01
• DOI: 10.1016/j.placenta.2011.12.006
• EISSN: 1532-3102
• ISSN: 0143-4004
• Language: English
• Keywords: Placenta; Pregnancy; Immunomodulation; Cell-Derived Microparticles; Organelle Size; Female; Pre-Eclampsia; Cytoplasmic Vesicles; Trophoblasts; Pregnancy Proteins; Particle Size; MicroRNAs; Humans; Exosomes