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Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.

Abstract:

The presentation pathways by which allogeneic peptides induce graft-versus-host disease (GVHD) are unclear. We developed a bone marrow transplant (BMT) system in mice whereby presentation of a processed recipient peptide within major histocompatibility complex (MHC) class II molecules could be spatially and temporally quantified. Whereas donor antigen presenting cells (APCs) could induce lethal acute GVHD via MHC class II, recipient APCs were 100-1,000 times more potent in this regard. After ...

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Publisher copy:
10.1038/nm.2597

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Journal:
Nature medicine
Volume:
18
Issue:
1
Pages:
135-142
Publication date:
2012-01-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:39820792-780e-4069-92da-d9c7f0f3e344
Source identifiers:
400739
Local pid:
pubs:400739

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