Journal article
Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.
- Abstract:
-
The presentation pathways by which allogeneic peptides induce graft-versus-host disease (GVHD) are unclear. We developed a bone marrow transplant (BMT) system in mice whereby presentation of a processed recipient peptide within major histocompatibility complex (MHC) class II molecules could be spatially and temporally quantified. Whereas donor antigen presenting cells (APCs) could induce lethal acute GVHD via MHC class II, recipient APCs were 100-1,000 times more potent in this regard. After ...
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- Publisher copy:
- 10.1038/nm.2597
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Authors
Bibliographic Details
- Journal:
- Nature medicine
- Volume:
- 18
- Issue:
- 1
- Pages:
- 135-142
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- Source identifiers:
-
400739
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:400739
- UUID:
-
uuid:39820792-780e-4069-92da-d9c7f0f3e344
- Local pid:
- pubs:400739
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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