A divergent CFTR homologue: highly regulated salt transport in the euryhaline teleost F. heteroclitus.

Journal article

The killifish, Fundulus heteroclitus, is a euryhaline teleost fish capable of adapting rapidly to transfer from freshwater (FW) to four times seawater (SW). To investigate osmoregulation at a molecular level, a 5.7-kilobase cDNA homologous to human cystic fibrosis transmembrane conductance regulator (hCFTR) was isolated from a gill cDNA library from SW-adapted killifish. This cDNA encodes a protein product (kfCFTR) that is 59% identical to hCFTR, the most divergent form of CFTR characterized ...

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Authors: Singer, T; Tucker, S; Marshall, W; Higgins, C

• Publication status: Published
• Journal: American journal of physiology
• Volume: 274
• Issue: 3 Pt 1
• Pages: C715-C723
• Publication date: 1998-03-01
• ISSN: 0002-9513
• Language: English
• Keywords: Amino Acid Sequence; Animals; DNA, Complementary; Adaptation, Physiological; Calcium Channels; Sequence Alignment; Cystic Fibrosis Transmembrane Conductance Regulator; Killifishes; Humans; Water-Electrolyte Balance; Molecular Sequence Data; Cyclic AMP; Xenopus; Gene Expression