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Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases.

Abstract:

Tumor necrosis factor (TNF) receptor-associated protein 1(TRAP1/HSP75) is a heat shock protein, highly homologous to HSP90, which acts as a molecular chaperone to retinoblastoma protein (Rb) during cellular stress although the current literature suggests that this protein could have additional functions. The aim of this study was to identify the pathways regulated by TRAP1. TRAP1 was silenced by siRNA in A549 cells and re-expressed by stable transfection in MDA231 cells. After growing the cel...

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Publication status:
Published

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Authors


Agorreta, J More by this author
Cesario, A More by this author
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Journal:
Cancer letters
Volume:
296
Issue:
2
Pages:
194-205
Publication date:
2010-10-05
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:39708534-43b6-4d00-a81e-e0280ecec1d8
Source identifiers:
125291
Local pid:
pubs:125291

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