Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effects.

Journal article

Attention-deficit/hyperactivity disorder (ADHD) and reading disability (RD) are common highly heritable disorders of childhood, which frequently co-occur. Data from twin and family studies suggest that this overlap is, in part, due to shared genetic underpinnings. Here, we report the first genome-wide linkage analysis of measures of reading ability in children with ADHD, using a sample of 233 affected sibling pairs who previously participated in a genome-wide scan for susceptibility loci in A...

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Authors: Loo, S; Fisher, S; Francks, C; Ogdie, M; MacPhie, I

• Publication status: Published
• Journal: Molecular psychiatry
• Volume: 9
• Issue: 5
• Pages: 485-493
• Publication date: 2004-05-01
• DOI: 10.1038/sj.mp.4001450
• EISSN: 1476-5578
• ISSN: 1359-4184
• Language: English
• Keywords: Child; Adolescent; Child, Preschool; Quantitative Trait Loci; Attention Deficit Disorder with Hyperactivity; Reading; Genome, Human; Genetic Linkage; Models, Genetic; Male; Chromosomes, Human; Humans; Siblings; Quantitative Trait, Heritable; Comorbidity; Computer Simulation; Genetic Predisposition to Disease; Female; Dyslexia