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SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon.

Abstract:

Protein targeting to the endoplasmic reticulum (ER) membrane is regulated by three GTPases, the 54 kDa subunit of the signal recognition particle (SRP) and the alpha- and beta-subunits of the SRP receptor (SR). Using a soluble form of SR and an XTP-binding mutant of SRbeta, we show that SRbeta is essential for protein translocation across the ER membrane. SRbeta can be cross-linked to a 21 kDa ribosomal protein in its empty and GDP-bound state, but not when GTP is bound. GTP binding to SRbeta...

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Publisher copy:
10.1093/emboj/20.9.2338

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Journal:
The EMBO journal
Volume:
20
Issue:
9
Pages:
2338-2347
Publication date:
2001-05-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:396b53ea-1220-443b-9226-ff2f6885e8ec
Source identifiers:
263650
Local pid:
pubs:263650

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