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Journal article

The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study.

Abstract:

AIMS: Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to assess KDR activation and novel inhibitors of KDR activation in clinical trials. METHODS AND RESULTS: Three monoclonal antibodies and one rabbit polyclonal antiserum were produced...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
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Journal:
Histopathology
Volume:
43
Issue:
1
Pages:
33-39
Publication date:
2003-07-01
DOI:
EISSN:
1365-2559
ISSN:
0309-0167
Source identifiers:
119340
Language:
English
Keywords:
Pubs id:
pubs:119340
UUID:
uuid:396523b3-3a5b-4387-a6d9-9de424ed04f6
Local pid:
pubs:119340
Deposit date:
2012-12-19

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