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Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.

Abstract:

Genetic variability is a hallmark of RNA virus populations. However, transmission to a new host often results in a marked decrease in population diversity. This genetic bottlenecking is observed during hepatitis C virus (HCV) transmission and can arise via a selective sweep or through the founder effect. To model HCV transmission, we utilized chimeric SCID/Alb-uPA mice with transplanted human hepatocytes and infected them with a human serum HCV inoculum. E1E2 glycoprotein gene sequences in th...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.01079-12

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Journal:
Journal of virology
Volume:
86
Issue:
22
Pages:
11956-11966
Publication date:
2012-11-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
344158

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