Journal article
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease
- Abstract:
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Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of proteins undergoing amyloidogenic processes. Here we report that the molecular tweezer CLR01 decreased aggregation and toxicity in induced pluripotent stem cell-derived dopaminergic cultures treated with PD brain protein extracts. In microfluidic ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 8.7MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-020-18689-x
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Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 11
- Article number:
- 4885
- Publication date:
- 2020-09-28
- Acceptance date:
- 2020-08-27
- DOI:
- ISSN:
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2041-1723
Item Description
- Language:
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English
- Pubs id:
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1129719
- Local pid:
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pubs:1129719
- Deposit date:
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2020-09-02
Terms of use
- Copyright holder:
- Bengoa-Vergniory et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. This article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visithttp://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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