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CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

Abstract:

Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of proteins undergoing amyloidogenic processes. Here we report that the molecular tweezer CLR01 decreased aggregation and toxicity in induced pluripotent stem cell-derived dopaminergic cultures treated with PD brain protein extracts. In microfluidic ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-18689-x

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Nuffield College
Faggiani, E More by this author
Ramos-Gonzalez, P More by this author
Connor-Robson, N More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Article number:
4885
Publication date:
2020-09-28
Acceptance date:
2020-08-27
DOI:
ISSN:
2041-1723
Pubs id:
1129719
Local pid:
pubs:1129719
Language:
English

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