Journal article
Biphasic voltage‐dependent inactivation of human NaV1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin‐secreting cells
- Abstract:
-
Pancreatic β-cells are equipped with voltage-gated Na+ channels that undergo biphasic voltage-dependent steady-state inactivation. A small Na+ current component (10-15%) inactivates over physiological membrane potentials and contributes to action potential firing. However, the major Na+ channel component is completely inactivated at -90 to -80 mV and is therefore inactive in the β-cell. It has been proposed that the biphasic inactivation reflects the contribution of different NaV α-subunits. ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Wellcome Trust
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Funding agency for:
Rorsman, P
Grant:
Senior Investigator Award
Bibliographic Details
- Publisher:
- Physiological Society Publisher's website
- Journal:
- Journal of Physiology Journal website
- Volume:
- 596
- Issue:
- 9
- Pages:
- 1601-1626
- Publication date:
- 2018-03-30
- Acceptance date:
- 2018-02-06
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- Pmid:
-
29441586
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:824933
- UUID:
-
uuid:3962dfd3-41af-4641-9db1-70a5ee42e3c6
- Local pid:
- pubs:824933
- Source identifiers:
-
824933
- Deposit date:
- 2018-04-04
Terms of use
- Copyright holder:
- Godazgar et al
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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