Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy.

Journal article

OBJECTIVE: The purpose of the present study was to measure absolute concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP) in normal, hypertrophied, and failing human heart. BACKGROUND: Conflicting evidence exists on the extent of changes of high-energy phosphate metabolites in hypertrophied and failing human heart. Previous reports using phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) have quantified metabolites in relative terms only. However, this analysis cann...

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Authors: Beer, M; Seyfarth, T; Sandstede, J; Landschütz, W; Lipke, C

• Publication status: Published
• Journal: Journal of the American College of Cardiology
• Volume: 40
• Issue: 7
• Pages: 1267-1274
• Publication date: 2002-10-01
• DOI: 10.1016/s0735-1097(02)02160-5
• EISSN: 1558-3597
• ISSN: 0735-1097
• Language: English
• Keywords: Case-Control Studies; Adenosine Triphosphate; Myocardium; Middle Aged; Aged; Aortic Valve Stenosis; Adult; Energy Metabolism; Stroke Volume; Male; Imaging, Three-Dimensional; Hypertension; Female; Phosphocreatine; Ventricular Function, Left; Magnetic Resonance Imaging; Hypertrophy, Left Ventricular; Aged, 80 and over; Bias (Epidemiology); Humans; Cardiomyopathy, Dilated; Magnetic Resonance Spectroscopy; Phosphorus Isotopes