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Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues.

Abstract:

Sulfonylureas are widely used to stimulate insulin secretion in type 2 diabetic patients because they close adenosine triphosphate-sensitive potassium (K(ATP)) channels in the pancreatic beta-cell membrane. This action is mediated by binding of the drug to the sulfonylurea receptor (SUR1) subunit of the channel. K(ATP) channels are also present in a range of extrapancreatic tissues, but many of these contain an alternative type of SUR subunit (SUR2A in heart and SUR2B in smooth muscle). The s...

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Publication status:
Published

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Publisher copy:
10.1053/meta.2000.17822

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Volume:
49
Issue:
10 Suppl 2
Pages:
3-6
Host title:
Metabolism: clinical and experimental
Publication date:
2000-10-01
Event location:
UNITED STATES
DOI:
EISSN:
1532-8600
ISSN:
0026-0495
Source identifiers:
114513
Keywords:
Pubs id:
pubs:114513
UUID:
uuid:39594954-a1e5-4465-a8fa-41f2e44291f9
Local pid:
pubs:114513
Deposit date:
2012-12-19

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