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Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals.

Abstract:

OBJECTIVE: Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease. DESIGN: Thirty-five high-risk HIV-seronegative and 99 HIV-seropositive Danish homosexual men followed form 1985 to 1996 and 37 blood donors were analysed for their CKR-5 gen...

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Authors


Eugen-Olsen, J More by this author
Iversen, AK More by this author
Koppelhus, U More by this author
Pedersen, C More by this author
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Journal:
AIDS (London, England)
Volume:
11
Issue:
3
Pages:
305-310
Publication date:
1997-03-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:394da874-ef28-46ed-9f25-55f6b5c9a787
Source identifiers:
68078
Local pid:
pubs:68078

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