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DNA-recognition process described by MD simulations of the lactose repressor protein on a specific and a non-specific DNA sequence.

Abstract:

The lactose repressor protein may bind DNA in two possible configurations: a specific one, if the DNA sequence corresponds to a binding site, and a non-specific one otherwise. To find its target sequences, the lactose repressor first binds non-specifically to DNA, and subsequently, it rapidly searches for a binding site. Atomic structures of non-specific and specific complexes are available from crystallographic and nuclear magnetic resonance experiments. However, what remains unknown is a de...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkt099

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
Journal:
Nucleic acids research
Volume:
41
Issue:
7
Pages:
3963-3972
Publication date:
2013-04-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:394c43c4-a8f7-42ec-a6c5-ff12c49ff9b1
Source identifiers:
387133
Local pid:
pubs:387133

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