An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine.

Journal article

A novael means of measuring and analysing behavioural effects of dopamine agonists is described and illustrated by a comparison of the effects of d-amphetamine and apomorphine in the rat. d-Amphetamine (0--15 mg/kg IP) produced significant dose- and time-dependent changes in responses such as locomotion, rearing and sniffing, but not in licking or gnawing. In contrast, apomorphine (0--5 mg/kg SC) produced significant increases in licking and gnawing, as well as in locomotion and sniffing, but...

Expand abstract

Authors: Fray, P; Sahakian, B; Robbins, T; Koob, G; Iversen, S

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 69
• Issue: 3
• Pages: 253-259
• Publication date: 1980-01-01
• DOI: 10.1007/bf00433091
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Dextroamphetamine; Stereotyped Behavior; Humans; Apomorphine; Male; Dose-Response Relationship, Drug; Animals; Behavior, Animal; Rats; Dopamine; Motor Activity