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Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Abstract:

Pyruvate dehydrogenase (PDH) is a key regulator of cardiac substrate selection and is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition. The extent to which chronic upregulation of PDK protein levels, acutely increased PDK activity and acute feedback inhibition limit PDH flux remains unclear because existing in vitro assessment methods inherently disrupt the regulation of the enzyme complex. We have demonstrated previously that hyperpolaris...

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Publication status:
Published

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Publisher copy:
10.1002/nbm.1668

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
NMR in biomedicine
Volume:
24
Issue:
8
Pages:
980-987
Publication date:
2011-10-01
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Source identifiers:
179911
Language:
English
Keywords:
Pubs id:
pubs:179911
UUID:
uuid:3943e17f-5cbe-476c-a450-6a1cb93f07e6
Local pid:
pubs:179911
Deposit date:
2012-12-19

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