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Thesis

Development of ligands for the TRIM33 bromodomain

Abstract:

Epigenetic information is encoded in a wide range of histone modifications, which gives rise to the “histone code” and brings an additional level of complexity to the control of gene expression. The proteins involved include “writers”, “erasers”, and “readers”, which install, remove, and recognise histone modifications, respectively. Given the involvement of epigenetics in diseases, including cancer, epigenetic regulation presents opportunities for the development of novel therapeutics. Un...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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