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Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).

Abstract:

Inward rectifier (Kir) potassium channels contribute to the control of electrical activity in excitable tissues and their activity is modulated by many biochemical factors, including protons. Heteromeric Kir4.1-Kir5.1 channels are highly pH sensitive within the physiological range of pH changes and are strongly expressed by the peripheral chemosensors as well as in the brainstem pH-sensitive areas which mediate respiratory responses to changes in blood and brain levels of P(CO(2))/[H(+)]. In ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Gourine, AV More by this author
Journal:
Experimental physiology
Volume:
96
Issue:
4
Pages:
451-459
Publication date:
2011-04-05
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
URN:
uuid:39356e54-a8b2-417e-9402-050e92c35bcc
Source identifiers:
127350
Local pid:
pubs:127350

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