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Journal article

Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.

Abstract:

The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance of various proteinases and proteinase.inhibitor complexes, including thrombospondin (TSP)-dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector of extracellular matrix remodeling and cancer progression. However, the zymogen of MMP-2 (pro-MMP-2) mostly occurs in tissues as a complex with the tissue inhibitor of MMPs (TIMP-2). Here we show that clearance of the pro-M...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m406792200

Authors


Emonard, H More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Robinet, A More by this author
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Journal:
The Journal of biological chemistry
Volume:
279
Issue:
52
Pages:
54944-54951
Publication date:
2004-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:39346e28-2461-4065-838f-030ab6325841
Source identifiers:
227314
Local pid:
pubs:227314

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