Journal article
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
- Abstract:
-
The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance of various proteinases and proteinase.inhibitor complexes, including thrombospondin (TSP)-dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector of extracellular matrix remodeling and cancer progression. However, the zymogen of MMP-2 (pro-MMP-2) mostly occurs in tissues as a complex with the tissue inhibitor of MMPs (TIMP-2). Here we show that clearance of the pro-M...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m406792200
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 279
- Issue:
- 52
- Pages:
- 54944-54951
- Publication date:
- 2004-12-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
227314
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:227314
- UUID:
-
uuid:39346e28-2461-4065-838f-030ab6325841
- Local pid:
- pubs:227314
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2004
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