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Signaling and structures underpinning conducted vasodilation in human and porcine intramyocardial coronary arteries

Abstract:

Background: Adequate blood flow into coronary micro-arteries is essential for myocardial function. Here we assess the mechanisms responsible for amplifying blood flow into myogenically-contracting human and porcine intramyocardial micro-arteries ex vivo using endothelium-dependent and -independent vasodilators.

Methods: Human and porcine atrial and ventricular small intramyocardial coronary arteries (IMCAs) were studied with pressure myography and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fcvm.2022.980628

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0002-8014-2775
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More from this funder
Name:
British Heart Foundation
Grant:
FS/13/16/30199
PG/20/10260
PG/18/11/33552
FS/08/033/25111
Publisher:
Frontiers Media
Journal:
Frontiers in Cardiovascular Medicine More from this journal
Volume:
9
Article number:
980628
Publication date:
2022-08-12
Acceptance date:
2022-07-26
DOI:
EISSN:
2297-055X
Pmid:
36035957
Language:
English
Keywords:
Pubs id:
1276408
Local pid:
pubs:1276408
Deposit date:
2023-01-18

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