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Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.

Abstract:

Osteogenesis imperfecta (OI or brittle bone disease) is a disorder of connective tissues caused by mutations in the collagen genes. We previously showed that intrauterine transplantation of human blood fetal stem/stromal cells in OI mice (oim) resulted in a significant reduction of bone fracture. This work examines the cellular mechanisms and mechanical bone modifications underlying these therapeutic effects, particularly examining the direct effects of donor collagen expression on bone mater...

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Publication status:
Published

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Authors


Vanleene, M More by this author
Saldanha, Z More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Blood
Volume:
117
Issue:
3
Pages:
1053-1060
Publication date:
2011-01-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3910dd22-aa93-411b-a6c5-afb0cc27bacb
Source identifiers:
223538
Local pid:
pubs:223538

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