Journal article
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.
- Abstract:
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Background
Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene. Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin–piperaquine, are losing clinical effectiveness, prompting invest...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.0MB)
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- Publisher copy:
- 10.1186/s12936-017-1845-5
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Authors
Funding
+ Bill and Melinda Gates Foundation
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Funding agency for:
White, N
Grant:
OPP104063
Department for International Development
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University of Oxford
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Malaria Journal Journal website
- Volume:
- 16
- Issue:
- 1
- Pages:
- 195
- Publication date:
- 2017-05-01
- Acceptance date:
- 2017-04-29
- DOI:
- ISSN:
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1475-2875
- Source identifiers:
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695728
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:695728
- UUID:
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uuid:390dfc2a-487f-4449-b630-88cf2e2f13ed
- Local pid:
- pubs:695728
- Deposit date:
- 2017-05-25
Terms of use
- Copyright holder:
- White et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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