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Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.

Abstract:

Background

Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene. Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin–piperaquine, are losing clinical effectiveness, prompting invest...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-017-1845-5

Authors


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Department for International Development More from this funder
University of Oxford More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
16
Issue:
1
Pages:
195
Publication date:
2017-05-05
Acceptance date:
2017-04-29
DOI:
ISSN:
1475-2875
Pubs id:
pubs:695728
URN:
uri:390dfc2a-487f-4449-b630-88cf2e2f13ed
UUID:
uuid:390dfc2a-487f-4449-b630-88cf2e2f13ed
Local pid:
pubs:695728

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