- Abstract:
-
Background
Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations in the PF3D7_1343700 pfkelch13 gene. Recent spread of artemisinin resistance and emerging piperaquine resistance in Southeast Asia show that artemisinin combination therapy, such as dihydroartemisinin–piperaquine, are losing clinical effectiveness, prompting invest...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.0MB)
-
- Publisher copy:
- 10.1186/s12936-017-1845-5
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- Publisher:
- BioMed Central Publisher's website
- Journal:
- Malaria Journal Journal website
- Volume:
- 16
- Issue:
- 1
- Pages:
- 195
- Publication date:
- 2017-05-05
- Acceptance date:
- 2017-04-29
- DOI:
- ISSN:
-
1475-2875
- Pubs id:
-
pubs:695728
- URN:
-
uri:390dfc2a-487f-4449-b630-88cf2e2f13ed
- UUID:
-
uuid:390dfc2a-487f-4449-b630-88cf2e2f13ed
- Local pid:
- pubs:695728
- Language:
- English
- Keywords:
- Copyright holder:
- White et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Journal article
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia.
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Department for International Development
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University of Oxford
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