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Journal article

Identification of the MMS22L-TONSL complex that promotes homologous recombination.

Abstract:

Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks. Here we identify a human Mms22-like protein (MMS22L) and an MMS22L-interacting protein, NFκBIL2/TONSL. Depletion of MMS22L or TONSL from human cells causes a high level of double-strand breaks (DSBs) during DNA replication. Both proteins accumulate at stressed replication forks, and depletion of MMS22L or TONSL from cells causes hypersensitivity to agents that cause S ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Molecular cell
Volume:
40
Issue:
4
Pages:
632-644
Publication date:
2010-11-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Source identifiers:
219759

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