Journal article
Identification of the MMS22L-TONSL complex that promotes homologous recombination.
- Abstract:
-
Budding yeast Mms22 is required for homologous recombination (HR)-mediated repair of stalled or broken DNA replication forks. Here we identify a human Mms22-like protein (MMS22L) and an MMS22L-interacting protein, NFκBIL2/TONSL. Depletion of MMS22L or TONSL from human cells causes a high level of double-strand breaks (DSBs) during DNA replication. Both proteins accumulate at stressed replication forks, and depletion of MMS22L or TONSL from cells causes hypersensitivity to agents that cause S ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.molcel.2010.10.023
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Authors
Bibliographic Details
- Journal:
- Molecular cell
- Volume:
- 40
- Issue:
- 4
- Pages:
- 632-644
- Publication date:
- 2010-11-01
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
219759
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:219759
- UUID:
-
uuid:390c75c8-bd41-48d0-987b-8af7227caae1
- Local pid:
- pubs:219759
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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