Thesis icon

Thesis

Investigating a role of HER3 in anti-HER2 target therapy in breast cancer

Abstract:

Background

HER2-positive breast cancer is a poor prognostic subgroup, even if treated with anti-HER2 directed therapy. Trastuzumab is an important HER2-targeting antibody but only limited patients respond to this drug, and acquired resistance is a common problem. HER3 has been shown to be a key candidate in mediating resistance to trastuzumab and other ErbB inhibitors. The aims of the project are to investigate the resistance mechanisms and the relevant biomarkers in relati...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
Division:
MSD
Department:
Oncology
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:39025871-f32f-4e38-bd14-c13dbc9301f6
Local pid:
ora:10596
Deposit date:
2015-03-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP