Thesis
Investigating a role of HER3 in anti-HER2 target therapy in breast cancer
- Abstract:
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Background
HER2-positive breast cancer is a poor prognostic subgroup, even if treated with anti-HER2 directed therapy. Trastuzumab is an important HER2-targeting antibody but only limited patients respond to this drug, and acquired resistance is a common problem. HER3 has been shown to be a key candidate in mediating resistance to trastuzumab and other ErbB inhibitors. The aims of the project are to investigate the resistance mechanisms and the relevant biomarkers in relati...
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Authors
Contributors
+ Kong, A
Division:
MSD
Department:
Oncology
Role:
Supervisor
+ Valentine, M
Division:
MSD
Department:
Oncology
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:39025871-f32f-4e38-bd14-c13dbc9301f6
- Local pid:
- ora:10596
- Deposit date:
- 2015-03-13
Terms of use
- Copyright holder:
- Hashimoto, K
- Copyright date:
- 10
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