Journal article icon

Journal article

Rapid transcriptional responses to serum exposure are associated with sensitivity and resistance to antibody-mediated complement killing in invasive Salmonella Typhimurium ST313

Abstract:

Background: Salmonella Typhimurium ST313 exhibits signatures of adaptation to invasive human infection, including higher resistance to humoral immune responses than gastrointestinal isolates. Full resistance to antibody-mediated complement killing (serum resistance) among nontyphoidal Salmonellae is uncommon, but selection of highly resistant strains could compromise vaccine-induced antibody immunity. Here, we address the hypothesis that serum resistance is due to a dist... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.12688/wellcomeopenres.15059.1

Authors


Expand authors...
Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
4
Issue:
2019
Article number:
74
Publication date:
2019-04-25
Acceptance date:
2019-06-10
DOI:
ISSN:
2398-502X
Language:
English
Keywords:
Pubs id:
pubs:1010609
UUID:
uuid:38f61f6b-7db5-49ed-9174-4ae67afbdfed
Local pid:
pubs:1010609
Deposit date:
2019-09-05

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP