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Journal article

Peptide anchor residue glycosylation: effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition.

Abstract:

This study extends our previous observation that glycopeptides bind to class I major histocompatibility complex (MHC) molecules and elicit carbohydrate-specific CTL responses. The Sendai virus nucleoprotein wild-type (WT) peptide (FAPGNYPAL) binds H-2Db using the P5-Asn as an anchor. The peptide K2 carrying a P5 serine substitution did not bind Db. Surprisingly, glycosylation of the serine (K2-O-GlcNAc) with N-acetylglucosamine (GlcNAc), a novel cytosolic O-linked glycosylation, partially res...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830251211

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Journal:
European journal of immunology
Volume:
25
Issue:
12
Pages:
3270-3276
Publication date:
1995-12-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:38efd787-b61b-41ad-958d-f202615d3fb6
Source identifiers:
35896
Local pid:
pubs:35896

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