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Lipid-based passivation in nanofluidics.

Abstract:

Stretching DNA in nanochannels is a useful tool for direct, visual studies of genomic DNA at the single molecule level. To facilitate the study of the interaction of linear DNA with proteins in nanochannels, we have implemented a highly effective passivation scheme based on lipid bilayers. We demonstrate virtually complete long-term passivation of nanochannel surfaces to a range of relevant reagents, including streptavidin-coated quantum dots, RecA proteins, and RecA-DNA complexes. We show th...

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Publication status:
Published

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Publisher copy:
10.1021/nl204535h

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Nano letters
Volume:
12
Issue:
5
Pages:
2260-2265
Publication date:
2012-05-05
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
URN:
uuid:38e97366-4e0c-436a-9a68-ea3f16f19e69
Source identifiers:
320343
Local pid:
pubs:320343
Language:
English
Keywords:

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