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Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.

Abstract:

The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1519690113

Authors


Nakaya, HI More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Cortese, M More by this author
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Grant:
FP7 Grant “Advanced Immunisation Technologies”
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Grant:
to the Oxford Biomedical Research Centre; U19AI090023; R37AI48638; R37DK057665; U19AI057266; AI100663-02
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Grant:
to the Human Immunology Unit
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Publication date:
2016-01-11
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:38e95b3f-586f-4dcf-b130-eb84d6feaa2a
Source identifiers:
584202
Local pid:
pubs:584202

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