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Journal article

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.

Abstract:

The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1519690113

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Grant:
FP7 Grant “Advanced Immunisation Technologies”
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Grant:
U19AI090023
R37DK057665
R37AI48638
to the Oxford Biomedical Research Centre
U19AI057266
AI100663-02
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Grant:
to the Human Immunology Unit
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Publication date:
2016-01-11
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
584202
Language:
English
Keywords:
Pubs id:
pubs:584202
UUID:
uuid:38e95b3f-586f-4dcf-b130-eb84d6feaa2a
Local pid:
pubs:584202
Deposit date:
2016-01-20

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