- Abstract:
-
The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells....
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Grant:
- to the Oxford Biomedical Research Centre; U19AI090023; R37AI48638; R37DK057665; U19AI057266; AI100663-02
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America Journal website
- Publication date:
- 2016-01-11
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:38e95b3f-586f-4dcf-b130-eb84d6feaa2a
- Source identifiers:
-
584202
- Local pid:
- pubs:584202
- Language:
- English
- Keywords:
- Copyright holder:
- Nakaya et al
- Copyright date:
- 2016
- Notes:
- Author(s) retain copyright; published by the National Academy of Sciences under license. Freely available online through the PNAS open access option. This is the publisher's version of the article. The final version is available online from the National Academy of Sciences at: [10.1073/pnas.1519690113]
Journal article
Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
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+ National Institute for Health Research
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