Journal article
Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
- Abstract:
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The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells....
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1073/pnas.1519690113
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Authors
Funding
+ National Institute for Health Research
More from this funder
Grant:
U19AI090023
R37DK057665
R37AI48638
to the Oxford Biomedical Research Centre
U19AI057266
AI100663-02
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America Journal website
- Publication date:
- 2016-01-11
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Source identifiers:
-
584202
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:584202
- UUID:
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uuid:38e95b3f-586f-4dcf-b130-eb84d6feaa2a
- Local pid:
- pubs:584202
- Deposit date:
- 2016-01-20
Terms of use
- Copyright holder:
- Nakaya et al
- Copyright date:
- 2016
- Notes:
- Author(s) retain copyright; published by the National Academy of Sciences under license. Freely available online through the PNAS open access option. This is the publisher's version of the article. The final version is available online from the National Academy of Sciences at: [10.1073/pnas.1519690113]
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