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A chiral relay auxiliary for the synthesis of homochiral alpha-amino acids

Abstract:
A new chiral auxiliary (3S)-N,N′-bis(p-methoxybenzyl)-3-isopropylpiperazine-2,5-dione 7 has been developed for the asymmetric synthesis of α-amino acids. The auxiliary 7 employs a novel chiral relay network based on non-stereogenic N-benzyl protecting groups which enhance the diastereoselectivity observed during alkylation of its C6 enolate 25.
Publication status:
Published

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Publisher copy:
10.1039/a803124j

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Epstein, SW More by this author
Ouzman, JVA More by this author
Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Issue:
15
Pages:
2321-2330
Publication date:
1998-08-07
DOI:
EISSN:
1364-5463
ISSN:
0300-922X
URN:
uuid:38e33efd-edb6-492e-877f-935ab6e966e1
Source identifiers:
110628
Local pid:
pubs:110628
Language:
English

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