- Abstract:
-
Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic variation which have involved the MHC, as well as highlighting likely future directions. As a consequence of its particular genomic structure, its remarkable polymorphism and its early implication in nu...
Expand abstract - Publisher copy:
- 10.1093/bfgp/elp010
-
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- Journal:
- Briefings in functional genomics and proteomics
- Volume:
- 8
- Issue:
- 5
- Pages:
- 379-394
- Publication date:
- 2009-09-05
- DOI:
- EISSN:
-
1477-4062
- ISSN:
-
1473-9550
- URN:
-
uuid:38d4165b-4a8e-41cf-aefd-af30d96be915
- Source identifiers:
-
27497
- Local pid:
- pubs:27497
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
The human Major Histocompatibility Complex as a paradigm in genomics research.
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