Journal article icon

Journal article

The human Major Histocompatibility Complex as a paradigm in genomics research.

Abstract:

Since its discovery more than 50 years ago, the human Major Histocompatibility Complex (MHC) on chromosome 6p21.3 has been at the forefront of human genetic research. Here, we review from a historical perspective the major advances in our understanding of the nature and consequences of genetic variation which have involved the MHC, as well as highlighting likely future directions. As a consequence of its particular genomic structure, its remarkable polymorphism and its early implication in nu...

Expand abstract

Actions


Access Document


Publisher copy:
10.1093/bfgp/elp010

Authors


Vandiedonck, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Briefings in functional genomics and proteomics
Volume:
8
Issue:
5
Pages:
379-394
Publication date:
2009-09-05
DOI:
EISSN:
1477-4062
ISSN:
1473-9550
URN:
uuid:38d4165b-4a8e-41cf-aefd-af30d96be915
Source identifiers:
27497
Local pid:
pubs:27497

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP