Journal article
Combinatorial Smad2/3 activities downstream of nodal signaling maintain embryonic/extra-embryonic cell identities during lineage priming
- Abstract:
-
Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implantation. To learn more about the molecular disturbances underlying this abrupt failure, here we characterized Smad2/3-deficient embryonic stem cells (ESCs). We found that Smad2/3 double-knockout ESC...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Senft, A
Robertson, E
Grant:
099840/Z/12/A
102811/Z/13/2
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 24
- Issue:
- 8
- Pages:
- 1977-1985.e7
- Publication date:
- 2018-08-21
- Acceptance date:
- 2018-07-22
- DOI:
- EISSN:
-
2211-1247
- Pmid:
-
30134160
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:909632
- UUID:
-
uuid:38d0adb2-dde6-4eb4-b560-f61ba4951933
- Local pid:
- pubs:909632
- Source identifiers:
-
909632
- Deposit date:
- 2018-09-19
Terms of use
- Copyright holder:
- Senft et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Author(s). This is an open access article under the CC BY license
- Licence:
- CC Attribution (CC BY)
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