Journal article icon

Journal article

Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.

Abstract:

Eukaryotic translation initiation factor 3 (eIF3) is a multisubunit complex that plays a central role in translation initiation. We show that fission yeast Sum1, which is structurally related to known eIF3 subunits in other species, is essential for translation initiation, whereas its overexpression results in reduced global translation. Sum1 is associated with the 40S ribosome and interacts stably with Int6, an eIF3 component, in vivo, suggesting that Sum1 is a component of the eIF3 complex....

Expand abstract

Actions


Access Document


Publisher copy:
10.1091/mbc.01-06-0301

Authors


Expand authors...
Journal:
Mol Biol Cell
Volume:
13
Issue:
5
Pages:
1626-1640
Publication date:
2002-05-01
DOI:
ISSN:
1059-1524
Source identifiers:
22599

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP