Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.

Journal article

Eukaryotic translation initiation factor 3 (eIF3) is a multisubunit complex that plays a central role in translation initiation. We show that fission yeast Sum1, which is structurally related to known eIF3 subunits in other species, is essential for translation initiation, whereas its overexpression results in reduced global translation. Sum1 is associated with the 40S ribosome and interacts stably with Int6, an eIF3 component, in vivo, suggesting that Sum1 is a component of the eIF3 complex....

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Authors: Dunand-Sauthier, I; Walker, C; Wilkinson, C; Gordon, C; Crane, R

• Journal: Mol Biol Cell
• Volume: 13
• Issue: 5
• Pages: 1626-1640
• Publication date: 2002-05-01
• DOI: 10.1091/mbc.01-06-0301
• ISSN: 1059-1524
• Language: English
• Keywords: Nuclear Proteins; Green Fluorescent Proteins; Repressor Proteins; Schizosaccharomyces; Proteasome Endopeptidase Complex; Luminescent Proteins; Protein Transport; Saccharomyces cerevisiae Proteins; Recombinant Fusion Proteins; Carrier Proteins; Protein Biosynthesis; Peptide Hydrolases; Schizosaccharomyces pombe Proteins; Osmotic Pressure; Eukaryotic Initiation Factor-3; Endopeptidases; Fungal Proteins; Hot Temperature; Macromolecular Substances