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A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) study.

Abstract:

The purpose of this study was to evaluate the maximum tolerated dose (MTD) and recommended dose of oxaliplatin given synchronously with 5-fluorouracil (5FU), leucovorin (LV) and preoperative pelvic radiation for primary unresectable, locally advanced, rectal cancer. Preoperative pelvic radiotherapy using a three- or four-field technique and megavoltage photons comprised 45 Gy given in 25 fractions, 1.8 Gy per fraction, and delivered with escalating doses of oxaliplatin in combination with low...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6602818

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Journal:
British journal of cancer
Volume:
93
Issue:
9
Pages:
993-998
Publication date:
2005-10-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Source identifiers:
237008

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