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Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection.

Abstract:

BACKGROUND and AIMS: Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in patients with acute HBV infection to clarify their pathogenetic role. METHODS: Three HLA-A2 peptide tetramers able to visualize HBV core, envelope, and polymerase epitope-specific cytotoxic T lymp...

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Publication status:
Published

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Journal:
Gastroenterology
Volume:
117
Issue:
6
Pages:
1386-1396
Publication date:
1999-12-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:38a190a6-f80d-4716-9fa1-6ac169a00e43
Source identifiers:
13712
Local pid:
pubs:13712

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