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Factors involved in inflammation-induced developmental white matter damage.

Abstract:

Developmental white matter damage is a brain pathology associated with several long-term neurological disorders. An inflammatory insult has been suggested as the major instigating event. This study investigated the relative influence of inflammation, blood-brain barrier permeability and glial ontogeny in white matter damage. Systemic inflammation was induced in Monodelphis domestica (opossum) by serial intraperitoneal injections of lipopolysaccharide at different stages of brain development. ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Johansson, PA More by this author
Dziegielewska, KM More by this author
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Journal:
Neuroscience letters
Volume:
451
Issue:
3
Pages:
232-236
Publication date:
2009-02-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:38990d23-290e-4c98-a0d8-5c5ea5be6b1b
Source identifiers:
260864
Local pid:
pubs:260864

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