- Abstract:
-
G protein-coupled receptors (GPCRs) represent one of the major targets of new drugs on the market given their roles as key membrane receptors in many cellular signalling pathways. Structure-based drug design has potential to be the most reliable method for novel drug discovery. Unfortunately, GPCR-ligand crystallisation for X-ray diffraction studies is very difficult to achieve. However, solution- and solid-state NMR approaches have been developed and have provided new insights, particularly ...
Expand abstract - Publisher copy:
- 10.1016/j.bbamem.2010.10.003
-
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- Journal:
- Biochimica et Biophysica Acta - Biomembranes
- Volume:
- 1808
- Issue:
- 6
- Pages:
- 1462-1475
- Publication date:
- 2011-06-05
- DOI:
- ISSN:
-
0005-2736
- URN:
-
uuid:3896998c-6ccf-4ca7-b03b-2e36221d9349
- Source identifiers:
-
149714
- Local pid:
- pubs:149714
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Solution- and solid-state NMR studies of GPCRs and their ligands
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