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Solution- and solid-state NMR studies of GPCRs and their ligands

Abstract:

G protein-coupled receptors (GPCRs) represent one of the major targets of new drugs on the market given their roles as key membrane receptors in many cellular signalling pathways. Structure-based drug design has potential to be the most reliable method for novel drug discovery. Unfortunately, GPCR-ligand crystallisation for X-ray diffraction studies is very difficult to achieve. However, solution- and solid-state NMR approaches have been developed and have provided new insights, particularly ...

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Authors


Tapaneeyakorn, S More by this author
Goddard, AD More by this author
Willis, CL More by this author
Journal:
Biochimica et Biophysica Acta - Biomembranes
Volume:
1808
Issue:
6
Pages:
1462-1475
Publication date:
2011-06-05
DOI:
ISSN:
0005-2736
URN:
uuid:3896998c-6ccf-4ca7-b03b-2e36221d9349
Source identifiers:
149714
Local pid:
pubs:149714

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