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Immunohistochemical method identifies lymphovascular invasion in a majority of oral squamous cell carcinomas and discriminates between blood and lymphatic vessel invasion.

Abstract:

Tumor invasion into blood and/or lymphatic channels is an important component of cancer staging and prognosis. Standard pathological methods do not provide sufficient contrast to discriminate between invasion into each type of vessel and are complicated by tissue retraction artifacts. We evaluated the ability of a triple-stain immunohistochemical method, combining cytokeratin, CD34, and podoplanin stains in a single section, to distinguish blood from lymphatic vascular invasion in oral squamo...

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Publication status:
Published

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Publisher copy:
10.1369/jhc.2008.950790

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Volume:
56
Issue:
9
Pages:
803-810
Publication date:
2008-09-05
DOI:
EISSN:
1551-5044
ISSN:
0022-1554
URN:
uuid:3891ea5f-ac80-45c4-9f70-affc85688aa2
Source identifiers:
130995
Local pid:
pubs:130995

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