Immunohistochemical method identifies lymphovascular invasion in a majority of oral squamous cell carcinomas and discriminates between blood and lymphatic vessel invasion.

Journal article

Tumor invasion into blood and/or lymphatic channels is an important component of cancer staging and prognosis. Standard pathological methods do not provide sufficient contrast to discriminate between invasion into each type of vessel and are complicated by tissue retraction artifacts. We evaluated the ability of a triple-stain immunohistochemical method, combining cytokeratin, CD34, and podoplanin stains in a single section, to distinguish blood from lymphatic vascular invasion in oral squamo...

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Authors: O'Donnell, R; Feldman, M; Mick, R; Muschel, R

• Publication status: Published
• Journal: journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
• Volume: 56
• Issue: 9
• Pages: 803-810
• Publication date: 2008-09-01
• DOI: 10.1369/jhc.2008.950790
• EISSN: 1551-5044
• ISSN: 0022-1554
• Language: English
• Keywords: Middle Aged; Blood Vessels; Neoplasm Invasiveness; Antigens, CD34; Immunohistochemistry; Membrane Glycoproteins; Lymphatic Vessels; Carcinoma, Squamous Cell; Mouth Neoplasms; Female; Humans; Male