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Journal article

Design principles of biochemical oscillators.

Abstract:

Cellular rhythms are generated by complex interactions among genes, proteins and metabolites. They are used to control every aspect of cell physiology, from signalling, motility and development to growth, division and death. We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction kinetics and proper balancing of the timescales of opposing chemical reactio...

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Publication status:
Published

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Publisher copy:
10.1038/nrm2530

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Journal:
Nature reviews. Molecular cell biology
Volume:
9
Issue:
12
Pages:
981-991
Publication date:
2008-12-01
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
Source identifiers:
99787
Language:
English
Keywords:
Pubs id:
pubs:99787
UUID:
uuid:388a8d40-b451-42b5-84f3-5679897dd51f
Local pid:
pubs:99787
Deposit date:
2012-12-19

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