Tumour necrosis factor synergises with gamma interferon on the induction of mRNA for DR alpha chain on thyrocytes from Graves' disease and non toxic goitre.

Journal article

In both thyroid autoimmune diseases Graves' and Hashimoto's thyroiditis, the epithelial thyroid follicular cells (TFC) have been shown to express HLA class II molecules, and can restimulate autoreactive T cells cloned from the diseased tissue. This aberrant class II expression is important in the mechanism of perpetuation of the disease process, therefore we have compared the effect of interferon gamma (IFN gamma) and tumour necrosis factor (TNF alpha) on the HLA-DR alpha mRNA expression of t...

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Authors: Kissonerghis, A; Grubeck-Loebenstein, B; Pirich, K; Feldmann, M; Londei, M

• Publisher: Informa Healthcare
• Journal: Autoimmunity
• Volume: 4
• Issue: 4
• Pages: 255-266
• Publication date: 1989-01-01
• DOI: 10.3109/08916938909014702
• EISSN: 1607-842X
• ISSN: 0891-6934
• Language: English
• Keywords: Thyrotropin; Interferon-gamma; Graves Disease; Drug Synergism; Thyroid Gland; Humans; HLA-DR Antigens; Tumor Necrosis Factor-alpha; RNA, Messenger; Goiter