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Mutual Regulation of Epicardial Adipose Tissue and Myocardial Redox State by PPAR-γ/Adiponectin Signalling

Abstract:

Rationale: Adiponectin has anti-inflammatory effects in experimental models but its role in the regulation of myocardial redox state in humans is unknown. Although adiponectin is released from epicardial adipose tissue (EpAT), it is unclear whether it exerts any paracrine effects on the human myocardium.

Objective: To explore the cross-talk between EpAT-derived adiponectin and myocardial redox state in the human heart.

Methods and Results: EpAT and atrial myocardium were...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1161/CIRCRESAHA.115.307856

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Lippincott, Williams and Wilkins Publisher's website
Journal:
Circulation Research Journal website
Volume:
118
Pages:
842-855
Publication date:
2016-01-21
DOI:
ISSN:
1524-4571
URN:
uuid:388503bc-3500-4d09-9dbb-45ad58d0b5dd
Source identifiers:
599390
Local pid:
pubs:599390

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