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Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate.

Abstract:

One-electron oxidation of (6R)-5,6,7,8-tetrahydrobiopterin (H(4)B) by the azide radical generates the radical cation (H(4)B(*)(+)) which rapidly deprotonates at physiological pH to give the neutral trihydrobiopterin radical (H(3)B(*)); pK(a) (H(4)B(*)(+) <==> H(3)B(*) + H(+)) = (5.2 +/- 0.1). In the absence of ascorbate both the H(4)B(*)(+) and H(3)B(*) radicals undergo disproportionation to form quinonoid dihydrobiopterin (qH(2)B) and the parent H(4)B with rate constants k(H(4)B(*)(+) ...

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Publication status:
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Authors


Stratford, MR More by this author
Wardman, P More by this author
Everett, SA More by this author
Journal:
Free radical biology and medicine
Volume:
32
Issue:
3
Pages:
203-211
Publication date:
2002-02-05
DOI:
EISSN:
1873-4596
ISSN:
0891-5849
URN:
uuid:3884d5a8-90a3-4794-a9bc-10717f1eae4a
Source identifiers:
131585
Local pid:
pubs:131585

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