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Journal article

Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59.

Abstract:

Pore-forming proteins containing the structurally conserved membrane attack complex/perforin fold play an important role in immunity and host-pathogen interactions. Intermedilysin (ILY) is an archetypal member of a cholesterol-dependent cytolysin subclass that hijacks the complement receptor CD59 to make cytotoxic pores in human cells. ILY directly competes for the membrane attack complex binding site on CD59, rendering cells susceptible to complement lysis. To understand how these bacterial ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Cell reports
Volume:
3
Issue:
5
Pages:
1369-1377
Publication date:
2013-05-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:387c94f1-4aae-47ff-b7bf-1fc6332b156a
Source identifiers:
401110
Local pid:
pubs:401110

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